Publications

This paper reviews the epidemiology of post-traumatic ankle OA, presents evidence of new treatment options might be successful at preventing ankle OA and highlights recent technical advances in understanding of the origins of ankle OA to identify directions for future research.

This research was led by Arthritis Foundation’s 2023 Ankle Arthritis Think Tank awardee Don Anderson, MD.

https://pubmed.ncbi.nlm.nih.gov/39269016/

This manuscript uses a database of over 40,000 patients with ACL reconstruction to determine the incidence of post-traumatic osteoarthritis and identify patient and perioperative factors associated with the development of arthritis after the surgery.

This project was led by Arthritis Foundation Chair of Osteoarthritis Research, David Felson, MD, MPH and contains contributions by Arthritis Foundation through the FastOA Initiative.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209532/ 
 

This manuscript details the design and rationale of a clinical trial of diet and exercise to prevent knee osteoarthritis in female patients over 50 years of age that struggle with obesity. This project is led by Stephen Messier, PhD, and includes multiple Arthritis Foundation-funded scientists. This project was co-funded by the Arthritis Foundation, NIH and other government agencies.

This edition of the HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery covers important topics covered in the 2023 Hip Osteoarthritis Clinical Studies Conference, including the epidemiology, detection and rehabilitation of people with hip osteoarthritis.

The series of research articles in this publication was guest edited by the Arthritis Foundation’s Jason Kim, PhD, vice president of osteoarthritis programs, and Mathias Bostrom, MD, associate surgeon-in-chief at HSS. In addition, Dr. Kim has authored several articles for this special edition. This project contains contributions by Arthritis Foundation Staff.

https://journals.sagepub.com/toc/hssa/19/4

This manuscript describes a new approach to enrich clinical trial enrollees with those likely to develop post traumatic OA quickly

This project was led by Arthritis Foundation Chair of Osteoarthritis Research David Felson. This project was funded by the Arthritis Foundation and contains contributions by Arthritis Foundation Staff.

https://pubmed.ncbi.nlm.nih.gov/37821213/

This manuscript describes the work of the Joint Effort Initiative (JEI), an international collaboration of clinicians, researchers, and consumer organizations with a shared vision of improving the implementation of osteoarthritis management programs (OAMPs). This study aimed to identify JEI's future priorities and guide direction.

This project contains contributions by Arthritis Foundation Staff.

https://pubmed.ncbi.nlm.nih.gov/37771392/

This second of a 2-part series of articles recounts the key points presented in a collaborative symposium sponsored jointly by the Arthritis Foundation and the American Orthopaedic Foot & Ankle Society with the intent to survey current treatment options for osteoarthritis (OA) of the foot and ankle. Opportunities for future research are discussed, such as developments in surgical options for ankle and the first metatarsophalangeal joint. The OA scientific community, including funding agencies, academia, industry, and regulatory agencies, must recognize the importance to patients of addressing the foot and ankle with improved basic, translational, and clinical research.

https://pubmed.ncbi.nlm.nih.gov/36262470/

This first of a 2-part series of articles recounts the key points presented in a collaborative symposium sponsored jointly by the Arthritis Foundation and the American Orthopaedic Foot & Ankle Society with the intent to survey the state of scientific knowledge related to incidence, diagnosis, pathologic mechanisms, and injection treatment options for osteoarthritis (OA) of the foot and ankle. Part 1 overviews areas of epidemiology and pathophysiology, current approaches in imaging, diagnostic and therapeutic injections, and genetics. Opportunities for future research are discussed. The OA scientific community, including funding agencies, academia, industry, and regulatory agencies, must recognize the needs of patients that suffer from arthritis of foot and ankle.

https://pubmed.ncbi.nlm.nih.gov/36262469/

This manuscript describes research regarding a new type of diagnostic technology, “optical biopsy”, for cartilage of OA patients.  This project was led by Arthritis Foundation funded scientist Michael Albro.  This project was funded by the Arthritis Foundation. 

https://pubmed.ncbi.nlm.nih.gov/34370873/

This manuscript describes research to elucidate how cartilage is broken down in an arthritic joint, could spur development of treatments that prevent the breakdown.  This project was led by Arthritis Foundation funded scientist Suneel Apte.  Aspects of this project was funded by the Arthritis Foundation. 

https://pubmed.ncbi.nlm.nih.gov/35339693/

Technical description of the AF-funded OACTN study called MOntelukast as a potential CHondroprotective treatment following Anterior cruciate ligament reconstruction (MOCHA Trial): study protocol for a double-blind, randomized, placebo-controlled clinical trial.  This project was led by Arthritis Foundation funded scientist Cale Jacobs.  This project was funded by the Arthritis Foundation. 

https://pubmed.ncbi.nlm.nih.gov/35101085/

Technical description of a new MRI technique for imaging knee cartilage to show biomechanical and microstructural changes for early OA.  This project was led by Arthritis Foundation funded scientist Xiaojuan Li.  Aspects of this project was funded by and contains contributions from the Arthritis Foundation and AF Science Staff. 

https://pubmed.ncbi.nlm.nih.gov/34491127/

A technical overview of the workshop, including clinical research challenges, biomarkers, and assessment of disease progression by AF Science Staff

https://www.arthritis.org/science/events-publications/oa-workshop-technical-highlights

Experts discussed many aspects of OA and development of drugs.  Topics included the epidemiology, challenges to assessing disease progression, potential biomarkers, difficulties evaluating long-term benefits to the patient, and other challenges to achieving FDA approval.  The workshop was co-sponsored by the FDA and the AF.

https://www.arthritis.org/science/events-publications/oa-drug-development-workshop-presentations-papers

The American College of Rheumatology (ACR) published its 2021 guideline for rheumatoid arthritis treatments.

https://pubmed.ncbi.nlm.nih.gov/34101387/

The ACR and AF organized expert committees to publish the 2019 guideline for OA management in hand, hip, and knee.

https://pubmed.ncbi.nlm.nih.gov/31908149/