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Publications

The Arthritis Foundation Science Staff, our funded scientists, and our partners contribute to the medical and scientific discourse by producing peer-reviewed manuscripts, guidelines, articles, white papers, and presentations. Read, review, and learn about the important work of science and research accomplished in rheumatoid arthritis (RA), osteoarthritis (OA), juvenile arthritis (JA) and the many related arthritidies.  

Patient and Operative Risk Factors for Osteoarthritis After Primary Anterior Cruciate Ligament Reconstruction

This manuscript uses a database of over 40,000 patients with ACL reconstruction to determine the incidence of post-traumatic osteoarthritis and identify patient and perioperative factors associated with the development of arthritis after the surgery.

This project was led by Arthritis Foundation Chair of Osteoarthritis Research, David Felson, MD, MPH and contains contributions by Arthritis Foundation through the FastOA Initiative.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209532/ 
 

Technical description of the Arthritis Foundation-funded randomized clinical trial TOPS (The Osteoarthritis Prevention Study)

This manuscript details the design and rationale of a clinical trial of diet and exercise to prevent knee osteoarthritis in female patients over 50 years of age that struggle with obesity. This project is led by Stephen Messier, PhD, and includes multiple Arthritis Foundation-funded scientists. This project was co-funded by the Arthritis Foundation, NIH and other government agencies.

Arthritis Foundation and Hospital for Special Surgery - Special Issue: The 2023 Hip Osteoarthritis Clinical Studies Conference

This edition of the HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery covers important topics covered in the 2023 Hip Osteoarthritis Clinical Studies Conference, including the epidemiology, detection and rehabilitation of people with hip osteoarthritis.

The series of research articles in this publication was guest edited by the Arthritis Foundation’s Jason Kim, PhD, vice president of osteoarthritis programs, and Mathias Bostrom, MD, associate surgeon-in-chief at HSS. In addition, Dr. Kim has authored several articles for this special edition. This project contains contributions by Arthritis Foundation Staff.

https://journals.sagepub.com/toc/hssa/19/4

New approach to testing treatments for osteoarthritis: FastOA

This manuscript describes a new approach to enrich clinical trial enrollees with those likely to develop post traumatic OA quickly

This project was led by Arthritis Foundation Chair of Osteoarthritis Research David Felson. This project was funded by the Arthritis Foundation and contains contributions by Arthritis Foundation Staff.

https://pubmed.ncbi.nlm.nih.gov/37821213/

The OARSI Joint Effort Initiative: Priorities for osteoarthritis management program implementation and research 2024-2028

This manuscript describes the work of the Joint Effort Initiative (JEI), an international collaboration of clinicians, researchers, and consumer organizations with a shared vision of improving the implementation of osteoarthritis management programs (OAMPs). This study aimed to identify JEI's future priorities and guide direction.

This project contains contributions by Arthritis Foundation Staff.

https://pubmed.ncbi.nlm.nih.gov/37771392/

Summary Report of the Arthritis Foundation and the American Orthopaedic Foot & Ankle Society's Symposium on Targets for Osteoarthritis Research: Part 2: Treatment Options

This second of a 2-part series of articles recounts the key points presented in a collaborative symposium sponsored jointly by the Arthritis Foundation and the American Orthopaedic Foot & Ankle Society with the intent to survey current treatment options for osteoarthritis (OA) of the foot and ankle. Opportunities for future research are discussed, such as developments in surgical options for ankle and the first metatarsophalangeal joint. The OA scientific community, including funding agencies, academia, industry, and regulatory agencies, must recognize the importance to patients of addressing the foot and ankle with improved basic, translational, and clinical research.

https://pubmed.ncbi.nlm.nih.gov/36262470/

Summary Report of the Arthritis Foundation and the American Orthopaedic Foot & Ankle Society's Symposium on Targets for Osteoarthritis Research: Part 1: Epidemiology, Pathophysiology, and Current Imaging Approaches

This first of a 2-part series of articles recounts the key points presented in a collaborative symposium sponsored jointly by the Arthritis Foundation and the American Orthopaedic Foot & Ankle Society with the intent to survey the state of scientific knowledge related to incidence, diagnosis, pathologic mechanisms, and injection treatment options for osteoarthritis (OA) of the foot and ankle. Part 1 overviews areas of epidemiology and pathophysiology, current approaches in imaging, diagnostic and therapeutic injections, and genetics. Opportunities for future research are discussed. The OA scientific community, including funding agencies, academia, industry, and regulatory agencies, must recognize the needs of patients that suffer from arthritis of foot and ankle.

https://pubmed.ncbi.nlm.nih.gov/36262469/

Raman needle arthroscopy for in vivo molecular assessment of cartilage

This manuscript describes research regarding a new type of diagnostic technology, “optical biopsy”, for cartilage of OA patients.  This project was led by Arthritis Foundation funded scientist Michael Albro.  This project was funded by the Arthritis Foundation. 

https://pubmed.ncbi.nlm.nih.gov/34370873/

Forward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1

This manuscript describes research to elucidate how cartilage is broken down in an arthritic joint, could spur development of treatments that prevent the breakdown.  This project was led by Arthritis Foundation funded scientist Suneel Apte.  Aspects of this project was funded by the Arthritis Foundation. 

https://pubmed.ncbi.nlm.nih.gov/35339693/

MOCHA Trial: study protocol for a double-blind, randomized, placebo-controlled clinical trial

Technical description of the AF-funded OACTN study called MOntelukast as a potential CHondroprotective treatment following Anterior cruciate ligament reconstruction (MOCHA Trial): study protocol for a double-blind, randomized, placebo-controlled clinical trial.  This project was led by Arthritis Foundation funded scientist Cale Jacobs.  This project was funded by the Arthritis Foundation. 

https://pubmed.ncbi.nlm.nih.gov/35101085/

The QIBA Profile for MRI-based Compositional Imaging of Knee Cartilage

Technical description of a new MRI technique for imaging knee cartilage to show biomechanical and microstructural changes for early OA.  This project was led by Arthritis Foundation funded scientist Xiaojuan Li.  Aspects of this project was funded by and contains contributions from the Arthritis Foundation and AF Science Staff. 

https://pubmed.ncbi.nlm.nih.gov/34491127/

OA Drug Development Workshop Technical Highlights

A technical overview of the workshop, including clinical research challenges, biomarkers, and assessment of disease progression by AF Science Staff

https://www.arthritis.org/science/events-publications/oa-workshop-technical-highlights

OA Drug Development Workshop Presentations and Papers

Experts discussed many aspects of OA and development of drugs.  Topics included the epidemiology, challenges to assessing disease progression, potential biomarkers, difficulties evaluating long-term benefits to the patient, and other challenges to achieving FDA approval.  The workshop was co-sponsored by the FDA and the AF.

https://www.arthritis.org/science/events-publications/oa-drug-development-workshop-presentations-papers

2021 ACR Guideline for the Treatment of Rheumatoid Arthritis

The American College of Rheumatology (ACR) published its 2021 guideline for rheumatoid arthritis treatments.

https://pubmed.ncbi.nlm.nih.gov/34101387/

2019 ACR/AF Guideline for Management of OA of the Hand, Hip, and Knee

The ACR and AF organized expert committees to publish the 2019 guideline for OA management in hand, hip, and knee.

https://pubmed.ncbi.nlm.nih.gov/31908149/

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